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pentobarbital decreases amounts of elvitegravir/cobicistat/emtricitabine/tenofovir DF by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May perhaps produce lack of virologic reaction and possible resistance.pentobarbital will decrease the extent or effect of fosamprenavir by impacting hepatic/intestinal enzyme CYP3A4 metabo